Diagnostic Evaluation of HPV DNA Test in Detecting Cervical Pre- Cancer: A Systematic Review
Introduction
Cervical cancer is a major public health issue globally, ranking as the fourth most common cancer among women, with an estimated 660000 new cases and 350,000 deaths reported worldwide in 2022.
1 The burden of cervical cancer is disproportionately higher in low- and middle-income countries, largely due to limited access to effective screening programs and timely treatment.
2 Early detection of cervical pre-cancerous lesions offers the best opportunity to prevent progression to invasive cervical cancer and reduce mortality.Persistent infection with oncogenic, or high-risk, human papillomavirus (HR-HPV) is now recognized as the central cause of cervical carcinogenesis.
3 Among the over 200 known HPV
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